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Organ-on-a-Chip Platform

From: €3,285.00

To: €3,527.00

Price as configured: €0.00

Availability: In stock

This platform is an easy way to start your research.
We already assembled all the right components you need for cell culturing experiments.

The only thing left for you to do.. is choose how many chips you want and add this platform to your cart!

1 x Fluidic Connect PRO OOC (for organ-on-a-chip)   +€1,745.00
1 x 4-Pack Top and Bottom OOC Layers   +€645.00

Price as configured: €0.00

The Load 'n Seal design of the OOC chip holder asures tight connections to the organ-on-a-chip devices. Together with the Teflon Connection Kit PRO, 1mm ID, that contains the tubing and the perfluoroelastomer ferrules, you have the best solution for the organ-on-a-chip devices in the web store.

Features and Benefits:
Fast, easy and robust fluidics connections;
future proof thanks to replaceable inserts;
durable light-weight design;
large chip viewing area possible;
compatible with upright and inverted microscopes

The layer containing the cell culture membrane is placed in between the top and bottom OOC layers to form two separate flow chambers. This allows the flow of two different fluids, either liquids or gases, on either side of the membrane. This dynamic microfluidic flow approach enables new and innovative ways to culture cells and tissues while offering precise and continuous control during the complete culturing process.

In these two papers the Organ-on-a-chip platform was used:
Navarro-Tableros, Victor, et al. "Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice." Stem Cell Reviews and Reports (2018): 1-19.

Kulthong, Kornphimol, et al. "Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners." RSC Advances 8.57 (2018): 32440-32453.

Product CodeOrgan-on-a-Chip Platform
DimensionsChipholder: 128 mm x 85,4 mm x 20 mm
Sealing mechanismLoad ‘n Seal
Maximum operation temperature80°C
Max. operating pressure10 bar
Sealing materialPerlast (FFKM)
ContentsConnection Kit: Teflon tubing and 5 FFKM ferrules
Length5 m tubing
Outer Diameter (OD)1/16 Inch (~1.6 mm)
Inner Diameter (ID)250 µm
Number of chips per pack4 top and bottom layers, 12 membrane middle layers
Distance between channel and top surfaceThickness top layer 1.1 mm
Distance between channel and bottom surfaceThickness bottom layer 0.7 mm
Total chip thickness2.6 mm (including middle layer)
Chip size45 mm x15 mm
Channel width11 mm, 2 channel, 1x on top of membrane, 1x on bottom of membrane
Channel height~200 µm (per channel)
Number of Inlets2 (1 inlet for flow channel on top membrane, 1 inlet for flow on bottom of membrane )
Number of outlets2 (1 outlet for flow channel on top membrane, 1 outlet for flow on bottom of membrane )
Inlet/outlet hole sizes on top of the chip1.7 mm
Inlet/outlet holes size at channel0.75 mm
Optical propertiesOptical clear view from all sides
Supplied in Fluidic slide?No
Material chipBorosilicate glass
Layer Thickness Carrier0.4 mm (middle layer)
Material Carrier LayerBorosilicate glass
Membrane MaterialPET
Thickness Membrane0.45µm pore size: 12µm thickness; 3µm µm pore size: 9µm; 8µm µm pore size: 16µm
Membrane Surface~1 cm²
Membrane Pore Density0.45µm pore size: 2.00 E+6 (cm2); 3µm µm pore size: 8.00 E+05 (cm2) 8µm pore size: 6.00 E+4 (cm2)
Membrane AppearanceTransparent
Membrane Surface TreatmentCell culture treated

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How do I clean and sterilize my resealable flow cells?

Is it possible to monitor oxygen levels?

It is possible to couple Micronit OOC device to commercial optical readers for dissolved gases in the culture medium. This option allows for applications such as the monitoring of the oxygen in the culture chamber.

Is it possible to control the oxygen concentration?

Micronit's OOC device is made of three glass layers. Glass has a very low gas permeability, making the system suitable for controlling gas concentrations. In case you use a syringe pump, the medium must be pre-conditioned to the right gas concentration. In case you use pneumatic pressurization systems, like Fluigent systems, specific gas mixtures can be used to condition the liquids during perfusion.

Is my OOC system compatible with my imaging systems?