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Organ-on-a-Chip Platform

From: €3,285.00

To: €3,527.00

Price as configured: €0.00

Availability: In stock

Quick start your research on Organ-on-a-Chip applications with these flow cells and their interfacing.

1 x Fluidic Connect PRO OOC (for organ-on-a-chip)   +€1,745.00
1 x 4-Pack Top and Bottom OOC Layers   +€645.00

Price as configured: €0.00

The ‘Organ-on-a-Chip Platform’ is a great place to start for researchers aiming to develop their own organ-on-a-chip [OOC] applications. This platform provides a double chamber flow cell and its interfacing. All you need to add is pumps and materials such as cells and fluids. what remains for you is doing what you are good at; biology! 

The flow cell is resealable and can be opened. It consists of two chambers where flow can be individually controlled. The membrane separates the two chambers.

Micronit does not do biological research on these components, but our customers do! Have a look at the three papers below in which our items were used. These papers show you more about the devices, they show you can do complex biology on them and they proof you can publish using them.


Navarro-Tableros, Victor, et al. "Islet-Like Structures Generated In Vitro from Adult Human Liver Stem Cells Revert Hyperglycemia in Diabetic SCID Mice." Stem Cell Reviews and Reports (2018): 1-19.


Li, Xiang, et al. "A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX." Lab on a Chip 18.17 (2018): 2614-2631.


Kulthong, Kornphimol, et al. "Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners." RSC Advances 8.57 (2018): 32440-32453.

Product CodeOrgan-on-a-Chip Platform
DimensionsChipholder: 128 mm x 85,4 mm x 20 mm
MaterialAluminium
Sealing mechanismLoad ‘n Seal
Maximum operation temperature80°C
Max. operating pressure10 bar
Sealing materialPerlast (FFKM)
ContentsConnection Kit: Teflon tubing and 5 FFKM ferrules
Length5 m tubing
Outer Diameter (OD)1/16 Inch (~1.6 mm)
Inner Diameter (ID)250 µm
Number of chips per pack4 top and bottom layers, 12 membrane middle layers
Distance between channel and top surfaceThickness top layer 1.1 mm
Distance between channel and bottom surfaceThickness bottom layer 0.7 mm
Total chip thickness2.6 mm (including middle layer)
Chip size45 mm x15 mm
Channel width11 mm, 2 channel, 1x on top of membrane, 1x on bottom of membrane
Channel height~200 µm (per channel)
Number of Inlets2 (1 inlet for flow channel on top membrane, 1 inlet for flow on bottom of membrane )
Number of outlets2 (1 outlet for flow channel on top membrane, 1 outlet for flow on bottom of membrane )
Inlet/outlet hole sizes on top of the chip1.7 mm
Inlet/outlet holes size at channel0.75 mm
Optical propertiesOptical clear view from all sides
Supplied in Fluidic slide?No
Material chipBorosilicate glass
Layer Thickness Carrier0.4 mm (middle layer)
Material Carrier LayerBorosilicate glass
Membrane MaterialPET
Thickness Membrane0.45µm pore size: 12µm thickness; 3µm µm pore size: 9µm; 8µm µm pore size: 16µm
Membrane Surface~1 cm²
Membrane Pore Density0.45µm pore size: 2.00 E+6 (cm2); 3µm µm pore size: 8.00 E+05 (cm2) 8µm pore size: 6.00 E+4 (cm2)
Membrane AppearanceTransparent
Membrane Surface TreatmentCell culture treated

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Quality

How do I clean and sterilize my resealable flow cells?

Is it possible to monitor oxygen levels?

It is possible to couple Micronit OOC device to commercial optical readers for dissolved gases in the culture medium. This option allows for applications such as the monitoring of the oxygen in the culture chamber.

Is it possible to control the oxygen concentration?

Micronit's OOC device is made of three glass layers. Glass has a very low gas permeability, making the system suitable for controlling gas concentrations. In case you use a syringe pump, the medium must be pre-conditioned to the right gas concentration. In case you use pneumatic pressurization systems, like Fluigent systems, specific gas mixtures can be used to condition the liquids during perfusion.

Is my OOC system compatible with my imaging systems?