Fluidic Connect Pro chip holder - topconnect - for organ-on-a-chip (OOC)

SKU

00750

Availability:

In stock

€1,832.00

Easy interfacing for OOC chips.

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Details

Fluidic Connect Pro chip holder for organ-on-a-chip (OOC). Ready to use all Micronit OOC chips. The Load 'n' Seal design ensures tight connections without breaking your chips. Together with the Fluidic Connect Pro Connection kit, that contains the tubing and the perfluoroelastomer ferrules, you have the best solution for all the organ-on-a-chip devices in the webstore.

Note: Never use ferrules from a different supplier this will cause leakage or can damage the chip.

Features and Benefits:

Fast, easy and robust fluidic connections
Future proof, thanks to replaceable inserts
Durable design
Smart sealing solutions to prevent chip cracking
Large chip view area possible
Compatible with upright and inverted microscopes

Kit contents

Casing
Fluidic Connect Pro Frame
Top insert (premounted)
Bottom insert (premounted)
Spare screws
Screwdriver
USB stick
Instruction Manual

More Information

More Information
Holder concept	Fluidic Connect Pro
Holder sub-type	Organ On Chip - Single slot

Product Questions (8)

Customer Questions

Can I use a ferrule from a alternative supplier, like for instance IDEX is offering, in combination with the Fluidic Connect Pro?

This will NOT work and will cause damage to the chip or holder. Our ferrules for use with the Fluidic Connect Pro are a Micronit proprietary design and also a specific grade of FFKM is used.

I have a Elveflow OB1 pressure based pump what connectors do I need?

Nuts and ferrules Elveflow uses 1/4-28 screw in connections on there reservoirs and sensors. To interface you will need Flangeless nuts 1/4-28 for 1/16" tubing, including compatible ferrules. Those nuts and ferrules are included in Elveflows "Kit Fittings Starter Pack Push-in".
This item wil look like this: In addition you will need our connection kit. Our Connection kit includes nuts or ferrules specificilly designed for our Fluidic Connect Pro, Fluidic Connect 4515 or side connect holders. Tubing included in "Kit Fittings Starter Pack Push-in" The 1/16"OD PTFE tubing included in the kit has a very large ID (1/32" ~0.79mm) and is from a relatively soft material, this is not so suitable for bot our Fluidic Connect Pro and Fluidic Connect 4515 holders as there's very limited wall thickness. We recommend alternative tubing, like ETFE with...

I have a Fluigent pressure based pump, what connectors do I need?

Lineup We recommend the dafault Fluigent kits (FLOW EZ™ SUPPLY KIT, FLUIWELL KIT or P-CAP KIT)
The P-cab or FLUIWELL KIT already contains 0.5m 1/16" OD FEP tubing with a ID of 500µm, when you use only limited pressures, you can try this tubing first and only order: For Fluidic Connect Pro our propriatary ferrules. For Fluidic Connect 4515 our propriatary flatbottom nuts and ferrules. For Sideconnect our propriatary ferrules. For optimal performance we recommend our complete connection kit, the FEP tubing might...

Publication: Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners.

Kulthong K, Duivenvoorde L, Mizera BZ, Rijkers D, Dam GT, Oegema G, Puzyn T, Bouwmeester H, Van Der Zande M. Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners. RSC Advances. 2018; 8(57): 32440-32453 Abstract Novel microfluidic technologies allow the manufacture of in vitro organ-on-a-chip systems that hold great promise to adequately recapitulate the biophysical and functional complexity of organs found in vivo. In this study, a gut-on-a-chip model was developed aiming to study the potential cellular association and transport of food contaminants. Intestinal epithelial cells (Caco-2) were cultured on a porous polyester membrane that was tightly clamped between two glass slides to form two separate flow chambers. Glass syringes, polytetrafluoroethylene tubing and glass microfluidic chips were selected to minimize...

Publication: Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models.

Kulthong K, Duivenvoorde L, Sun H, Confederat S, Wu J, Spenkelink B, de Haan L, Marin V, van der Zande M, Bouwmeester H. Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models. Toxicol In Vitro. 2020 Jun;65:104815 Abstract Dynamic flow in vitro models are currently widely explored for their applicability in drug development research. The application of gut-on-chip models in toxicology is lagging behind. Here we report the application of a gut-on-chip model for biokinetic studies and compare the observed biokinetics of reference compounds with those obtained using a conventional static in vitro ...

Publication: Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epithelia.

Kulthong K, Hooiveld GJEJ, Duivenvoorde L, Miro Estruch I, Marin V, van der Zande M, Bouwmeester H. Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epithelia. Sci Rep. 2021 Feb 5;11(1):3234. doi: 10.1038/s41598-021-82853-6. Abstract Gut-on-chip devices enable exposure of cells to a continuous flow of culture medium, inducing shear stresses and could thus better recapitulate the in vivo human intestinal environment in an in vitro epithelial model compared to static culture methods. We aimed to study if dynamic culture conditions affect the gene expression of Caco-2 cells cultured statically or dynamically in a gut-on-chip device and...

Publication: Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions.

Duivenvoorde LPM, Louisse J, Pinckaers NET, Nguyen T, van der Zande M. Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions. Sci Rep. 2021 May 14;11(1):10327. Abstract Flow conditions have been shown to be important in improving longevity and functionality of primary hepatocytes, but the impact of flow on HepaRG cells is largely unknown. We studied the expression of genes encoding CYP enzymes and transporter proteins and CYP1 and CYP3A4 activity during 8 weeks of culture in HepaRG cells cultured under static conditions (conventional 24-/96-well plate culture with common bicarbonate/CO2 buffering) and under flow conditions in an organ-on-chip (OOC) device. Since the OOC...

What are the dimension of the available view window using the resealable / OOC chip holder?

The view window on the bottom of the resealable/OOC chip holder has the dimensions as found in the picture below:

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